Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment
نویسندگان
چکیده
منابع مشابه
Bioengineering of rFVIIa Biopharmaceutical and Structure Characterization for Biosimilarity Assessment
Eptacog alfa (NovoSeven®) is a vitamin K-dependent recombinant Factor VIIa produced by genetic engineering from baby hamster kidney (BHK) cells as a single peptide chain of 406 residues. After activation, it consists of a light chain (LC) of 152 amino and a heavy chain (HC) of 254 amino acids. Recombinant FVIIa undergoes many post-translational modifications (PTMs). The first ten glutamic acids...
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ژورنال
عنوان ژورنال: Bioengineering
سال: 2019
ISSN: 2306-5354
DOI: 10.3390/bioengineering6030062